CROSSTALK BETWEEN ARYL HYDROCARBON RECEPTOR (AHR) AND BCL-2 PATHWAYS SUGGESTS THE USE OF AHR ANTAGONIST TO MAINTAIN NORMAL DIFFERENTIATION STATE OF MAMMARY EPITHELIAL CELLS DURING BCL-2 INHIBITION THERAPY

Introduction: Activating the aryl hydrocarbon receptor upon exposure to environmental pollutants promotes development of breast cancer stem cell (CSCs).BCL-2 family proteins protect cancer cells from the apoptotic effects of chemotherapeutic drugs.However, the crosstalk between AhR and the BCL-2 family in CSC development remains uninvestigated.Obje

A series of new C11 cyclopentenones 1-7 was BEARD OIL EUCALYPTUS W LIME isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp.The other didemnid ascidian Diplosoma sp.contained didemnenones 1, 2 and 5, and five known metabolites 8-12.The structures of aquarium 1-7 were elucidated by

Transportation is the second-largest sector contributing to greenhouse gas emissions due to CO2 gas generation from the combustion of fossil fuels.Electric vehicles (EVs) are believed to be a great solution to Metal Apple Watch Bands overcome this issue.EVs can reduce CO2 emissions because the vehicles use an electric motor as a propeller instead o

The research studies the sculptural formation in the third millennium: styles and trends, by taking the most important results of sculpture in the third millennium.The problem of the research is to search for the new sculptural formation in what it constitutes of social and human importance, and what are the important factors in forming the contemp